1. Changes in brain tissue similar to those of newborn in HIE were detected after 2 hours of hypoxia and ischemia. Meanwhile, swelling of kidneys, hemorrhage below encapsules, swellin of tubular epithelial cells, necrosing and falling of a few tubular epithelial cells, and narrowing of tubular lumens were observed. The basement membranes of renal tubules remained normal...
结果发现新生猪经2小时缺氧缺血后，在脑组织出现类似新生儿HIE病理损害的同时，肾脏出现肿胀，包膜下出血，肾小管上皮细胞肿胀，管腔变窄，少数上皮细胞坏死脱落，肾小管基膜完整，血清尿素氮及肌酐明显升高（P＜0.025及P＜0.05），表明在HIE状态下新生猪已出现肾脏的病理及功能损害，但损害程度较轻，解除缺氧72小时后，上述损害基本恢复正常。
2. objective: to investigate the relation of tumor necrosing foctor α and hepatis apoptosis and the effect of liver function in sepsis.
目的：探讨脓毒症大鼠肿瘤坏死因子 a与肝细胞凋亡的关系以及对肝功能的影响。